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EDUCATION
- College: Princeton University, Princeton, NJ
- Medical School: Weill Cornell Medical College at Cornell University
- Internship: Neurological Surgery, Columbia University Neurological Institute of New York
- Residency: Neurological Surgery, Columbia University Neurological Institute of New York
- Fellowship: Neuro-Oncology and Skull Base Fellow, Minimally Invasive Cranial Base Surgery Center at Thomas Jefferson University in Philadelphia, PA
BIOGRAPHY
Dr. Marc Otten is a fellowship-trained, board-certified neurosurgeon who specializes in treating disorders and injuries of the brain and spine, both non-surgically and surgically.
His research and sub-specialty training focus is on brain tumors, in addition to his work with patients who have degenerative spine disease, intervertebral disc disease, hydrocephalus and neuro-trauma. He treats meningiomas, pituitary tumors, acoustic neuromas, craniopharyngiomas, other skull base tumors, gliomas, Chiari malformation, and performs microvascular decompression (MVD) for trigeminal neuralgia and hemifacial spasm. Dr. Otten utilizes minimally invasive techniques such as endoscopy, laser ablation and awake craniotomies to minimize risk to patients.
He works with each patient to determine the best course of treatment that will get them back to the things they love to do as quickly as possible.
Dr. Otten earned his medical degree at Weill Cornell Medical College at Cornell University, where he graduated with honors. He completed a neurological surgery internship and residency at the Columbia University Neurological Institute of New York, where he was chief resident. He then completed a fellowship at the Minimally Invasive Cranial Base Surgery Center at Thomas Jefferson University in Philadelphia. There he received specialized training in endoscopic, micro-surgical and non-operative approaches to brain and spinal disorders.
His research on non-invasive methods for mapping brain function in patients with brain tumors to help maximize tumor resection, while maintaining optimum safety, has been published in leading peer-reviewed journals. He teaches medical students and fellow neurosurgeons new techniques to remove tumors in minimally invasive ways.
Dr. Otten is a member of the American Association of Neurologic Surgeons, the Congress of Neurosurgeons and the North American Skull Base Society. He was also a founding member of the Princeton Journal of Bioethics and the NYP/Westchester Hospital ethics committee.
AFFILIATIONS AND HONORS
• American Board of Neurologic Surgeons
• Fellow of the American Association of Neurologic Surgeons
• Member of the Congress of Neurosurgeons
• Member of the North American Skull Base Society
• Founding Member of the Princeton Journal of Bioethics
• Founding Member of the NYP/Westchester Hospital Ethics Committee
• Alpha Omega Alpha, Weill Medical College of Cornell University
• Served on a Clinical Leadership Group to Implement the Transition to Epic for Columbia
• Selected for Executive Committee for the ColumbiaDoctors Office in Tarrytown
• Served on a Perioperative Opioid Management Committee
• Selected for Columbia Faculty Leadership and Management Course
• George G. Reader Prize in Public Health, Weill Medical College of Cornell University
• Russek Fellow, American College of Cardiology
PEER-REVIEWED PUBLICATIONS
Dr. Otten has authored over 60 peer-reviewed publications. Please see his most notable publications below.
Motor Deficits Correlate with Resting State Motor Network Connectivity in Patients with Brain Tumours
Otten ML, Mikell CB, Youngerman BE, Liston C, Sisti MB, Bruce JN, Small SA, McKhann GM 2nd. Motor deficits correlate with resting state motor network connectivity in patients with brain tumours. Brain. 2012 Apr;135(Pt 4):1017-26. Epub 2012 Mar 8.
Near Real-Time Intraoperative Brain Tumor Diagnosis Using Stimulated Raman Histology and Deep Neural Networks
Hollon TC, Pandian B, Adapa AR, Urias E, Save AV, Khalsa SSS, Eichberg DG, D’Amico RS, Farooq ZU, Lewis S, Petridis PD, Marie T, Shah AH, Garton HJL, Maher CO, Heth JA, McKean EL, Sullivan SE, Hervey-Jumper SL, Patil PG, Thompson BG, Sagher O, McKhann GM 2nd, Komotar RJ, Ivan ME, Snuderl M, Otten ML, Johnson TD, Sisti MB, Bruce JN, Muraszko KM, Trautman J, Freudiger CW, Canoll P, Lee H, Camelo-Piragua S, Orringer DA. Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks. Nature Medicine. 2020 Jan;26(1):52-58.
Deconvolution of Cell Type-Specific Drug Responses in Human Tumor Tissue With Single-Cell RNA-Seq
Zhao W, Dovas A, Spinazzi EF, Levitin HM, Banu MA, Upadhyayula P, Sudhakar T, Marie T, Otten ML, Sisti MB, Bruce JN, Canoll P, Sims PA. Deconvolution of cell type-specific drug responses in human tumor tissue with single-cell RNA-seq. Genome Med. 2021 May 11;13(1):82.
A 53-Year-Old Woman With a Rapidly Progressive, Non-Enhancing Left Frontotemporal Lesion
Griepp D, Miller M, Sun Y, Tamir S, Straus Farber R Otten M Al-Dalahmah O. A 53-year-old woman with a rapidly progressive, non-enhancing left frontotemporal lesion. Brain Pathol. 2022 Nov 8:e13125.
A Standardized Approach to Treatment Over Objection in Patients Lacking Decision-Making Capacity Secondary to Neurological Disease
Ader J, Otten ML, Critchfield A, Prager KM. A Standardized Approach to Treatment Over Objection in Patients Lacking Decision-Making Capacity Secondary to Neurological Disease. Neurology: Clinical Practice. 2022 Oct;12(5):e105-e111.
Gross Total Versus Subtotal Surgical Resection in the Management of Craniopharyngiomas
Grewal MR, Spielman DB, Safi C, Overdevest JB, Otten M, Bruce J, Gudis DA. Gross Total Versus Subtotal Surgical Resection in the Management of Craniopharyngiomas. Allergy Rhinol (Providence). 2020 Oct 29;11:2152656720964158.
Presenting Features in 269 Patients With Clinically Nonfunctioning Pituitary Adenomas Enrolled in a Prospective Study
Freda PU, Bruce JN, Khandji AG, Jin Z, Hickman RA, Frey E, Reyes-Vidal C, Otten M, Wardlaw SL, Post KD. Presenting Features in 269 Patients With Clinically Nonfunctioning Pituitary Adenomas Enrolled in a Prospective Study. J Endocr Soc. 2020 Feb 18;4(4):bvaa021
Primary Episcleral Melanoma Consistent with Uveal Melanoma Mutations Treated by Excision and Gamma Knife Stereotactic Radiosurgery
Langevin ST, Chang E, Wang TJC, Deutsch I, Otten M, Marr BP. Primary Episcleral Melanoma Consistent with Uveal Melanoma Mutations Treated by Excision and Gamma Knife Stereotactic Radiosurgery. Ocul Oncol Pathol. 2020 Mar;6(2):93-98.
Plasma AgRP and Cortisol Levels in Cushing’s Disease: Evidence for the Regulation of AgRP by Glucocorticoids in Humans
Page-Wilson G, Peters JB, Panigrahi SK, Jacobs TP, Korner J, Otten M, Bruce JN, Wardlaw SL. Plasma AgRP and Cortisol Levels in Cushing’s Disease: Evidence for the Regulation of AgRP by Glucocorticoids in Humans. The Journal of Clinical Endocrinology & Metabolism. J Clin Endocrinol Metab. 2018 Dec 28.
Gonadotroph Tumours With a Low SF-1 Labelling Index are More Likely to Recur and are Associated With Enrichment of the PI3K-AKT Pathway
Hickman RA, Bruce JN, Otten M, Khandji AG, Flowers X, Siegelin M, Lopes MB, Faust PL, Freda PU. Gonadotroph tumours with a low SF-1 labelling index are more likely to recur and are associated with enrichment of the PI3K-AKT pathway. Neuropathol Appl Neurobiol. 2020 Oct 30.
Extent of BOLD Vascular Dysregulation Is Greater in Diffuse Gliomas without Isocitrate Dehydrogenase 1 R132H Mutation
Englander ZK, Horenstein CI, Bowden SG, Chow DS, Otten ML, Lignelli A, Bruce JN, Canoll P, Grinband J. Extent of BOLD Vascular Dysregulation Is Greater in Diffuse Gliomas without Isocitrate Dehydrogenase 1 R132H Mutation. Radiology. 2018 Jan 24:170790.
Bilateral "Rescue Strip" Technique for Endoscopic Endonasal Approaches to the Clivus
Kim M, Otten M, Overdevest JB, Gudis DA. Bilateral “Rescue Strip” Technique for Endoscopic Endonasal Approaches to the Clivus. Oper Neurosurg (Hagerstown). 2020 Oct 9:opaa304.
Treatment Strategies and Outcomes of Pediatric Esthesioneuroblastoma: A Systematic Review
Safi C, Spielman D, Otten M, Bruce JN, Feldstein N, Overdevest JB, Gudis DA. Treatment Strategies and Outcomes of Pediatric Esthesioneuroblastoma: A Systematic Review. Front Oncol. 2020 Jul 24;10:1247.
Endoscopic Petrous Apex Surgery: The Utilization of Frontal Sinus Instrumentation
Zheng Z, Otten ML, Bruce JN, Gudis DA. Endoscopic Petrous Apex Surgery: The Utilization of Frontal Sinus Instrumentation. J Craniofac Surg. 2020 Jul 3.
Pediatric Sinonasal and Skull Base Lesions
Riley CA, Soneru CP, Overdevest JB, Otten ML, Gudis DA. Pediatric sinonasal and skull base lesions. World J Otorhinolaryngol Head Neck Surg. 2020 Apr 8;6(2):118-124.
Frontal Osteoplastic Flap without Frontal Sinus Obliteration for Orbital Roof Decompression
Kim M, Otten M, Kazim M, Gudis DA. Frontal osteoplastic flap without frontal sinus obliteration for orbital roof decompression. Orbit. 2020 Apr 27:1-5.
Transoral Finger-Retraction for Endonasal Endoscopic Resection of Masseteric and Buccal Space Lesions
Husain Q, Otten ML, Gudis DA. Transoral Finger-Retraction for Endonasal Endoscopic Resection of Masseteric and Buccal Space Lesions. J Craniofac Surg. 2018 Dec 29.
Minimizing Septecetomy for Endoscopic Transsphenoidal Approaches to the Sellar and Suprasellar Regions: A Cadaveric Morphometric Study
Garcia HG, Otten M, Pyfer M, Singhal SJ, Iloreta AM, Kshettry VR, Farrell CJ, Nyquist G, Rosen M, Evans JJ. Minimizing Septecetomy for Endoscopic Transsphenoidal Approaches to the Sellar and Suprasellar Regions: A Cadaveric Morphometric Study. J Neurol Surg B Skull Base. 2016 Dec;77(6):479-484.
Is Reconstruction of the Sella Necessary to Prevent Optic Chiasm Prolapse and Cerebrospinal Fluid Leakage Following Endoscopic Resection of Pituitary Macroadenomas?
Otten ML, Petrone M, Nyquist GG, Rosen M, Evans JJ, Farrell CJ. Is Reconstruction of the Sella Necessary to Prevent Optic Chiasm Prolapse and Cerebrospinal Fluid Leakage Following Endoscopic Resection of Pituitary Macroadenomas? JHN Journal. 2015 10(2):13-15
Direct, Intraoperative Observation of ~0.1Hz Hemodynamic Oscillations in Awake Human Cortex: Implications for fMRI
Rayshubskiy A, Wojtasiewicz TJ, Mikell CB, Bouchard MB, Timerman D, Youngerman BE, McGovern RA, Otten ML, Canoll P, McKhann GM 2nd, Hillman EM. Direct, intraoperative observation of ~0.1Hz hemodynamic oscillations in awake human cortex: Implications for fMRI. Neuroimage. 2014 Feb 15;87:323-31.
Treatment of Early Childhood Medulloblastoma by Postoperative Chemotherapy Alone-a Critical Review
Komotar RJ, Otten ML, Garrett MC, Anderson RC. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone-a critical review. Clin Med Oncol. 2009 Mar 4;3:13-4.
A Review of Medical Treatments of Cerebral Vasospasm
Otten ML, Mocco J, Connolly ES Jr, Solomon RA. A review of medical treatments of cerebral vasospasm. Neurol Res. 2008 Jun;30(5):444-9
Preoperative Embolization in the Treatment of Choroid Plexus Papilloma in an Infant
Otten ML, Riina HA, Gobin YP, Souweidane MM. Preoperative embolization in the treatment of choroid plexus papilloma in an infant. J Neurosurg. 2006 Jun;104(6 Suppl):419-21.
Proendocrine Genes Coordinate the Pancreatic Islet Differentiation Program in Vitro
Gasa R, Mrejen C, Leachman N, Otten M, Barnes M, Wang J, Chakrabarti S, Mirmira R, German M. Proendocrine genes coordinate the pancreatic islet differentiation program in vitro. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13245-50.
BOOK CHAPTERS
Dr. Otten has authored over a dozen book chapters. Please see his most notable book chapters below.
Natural History of Spinal Cavernous Malformations
Otten M, Mccormick P. Natural history of spinal cavernous malformations. Handb Clin Neurol. 2017;143:233-239.
Olfactory Groove And Planum Sphenoidale Meningiomas: Endoscopic Approach
Evans JJ and Otten ML: Olfactory Groove And Planum Sphenoidale Meningiomas: Endoscopic Approach, Atlas of Neurosurgical Techniques: Brain, 2nd Ed. Sekhar and Fessler. Thieme. New York, NY 2015